The first versions of SimThyr have been developed by Johannes W. Dietrich at the Downdown Medical Hospitals of the Ludwig-Maximilian University of Munich from 1994 to 2000. Primary intention was to test hypotheses about dynamic behaviour of thyrotropic feedback control. One of the key results was a theory about pulsatile TSH secretion emerging from ultrashort feedback control at the anterior pituitary lobe - an assumption that has later been proved independently and with different methods by LJ Brokken, WM Wiersinga and MF Prummel from the University of Amsterdam.
SimThyr 2.0, released in August 2002 was the first easy-to-use version with a graphical user interface. It is available for classic Mac OS (Mac OS 6 to 9).
A new version, SimThyr 3.0, is available from 2011. Beginning with this version, SimThyr supports modern operating systems like Mac OS X, Linux and current Windows versions. This application has received numerous software awards.
Contributors
Johannes W. Dietrich: Initiator and main developer
Martin Adler: Technical advise
Matthias Holzer: Technical advise
Martin R. Fischer: General support
C. Renate Pickardt: Content related advice (thyroidology)
Ulla Mitzdorf: Content related advice (mathematical modelling)
References
Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2004). "Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis." Cybernetics and Systems 35 (4): 315-31. [DOI 10.1080/01969720490443354]
Dietrich, J. W. (2000). "Signal Storage in Metabolic Pathways: The ASIA Element." kybernetiknet 1 (3, 2000): 1-9.
Dietrich, J. W., M. R. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A novel systems theoretic approach to determine the secretion capacity of the thyroid gland." European Journal of Internal Medicine 10 (Suppl. 1) (May 1999): S34.
Dietrich, J. W., U. Mitzdorf, R. Weitkunat und C. R. Pickardt (1997). "The pituitary-thyroid feedback control: stability and oscillations in a new nonlinear model." Journal of Endocrinological Investigation 20 (Suppl. to no. 5): 100.
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